AI-Enabled Disease Surveillance and Outbreak Prediction: A Theoretical Account of Signal, Noise and Action in Data-Sparse Settings
DOI:
https://doi.org/10.68854/qchzs694Keywords:
disease surveillance, outbreak prediction, epidemic intelligence, artificial intelligence, early warning systems, data sparsity, reporting delay, public health response, Nigeria, AfricaAbstract
Artificial intelligence (AI) is frequently presented as a means of detecting infectious-disease outbreaks earlier, yet the settings in which early detection matters most, including Nigeria and much of sub-Saharan Africa, are those in which surveillance data are incomplete, delayed and unevenly reported. Research on the subject has divided into technical studies reporting high forecasting accuracy and policy analyses calling for stronger governance, and neither explains what a model can infer from sparse reports or when its output leads to action. This paper addresses that gap. Using a conceptual, theory-building design, the study conducted a structured integrative review of peer-reviewed journal articles published between 2023 and 2026. Records were identified through purposive, criterion-based searches of PubMed/MEDLINE and Google Scholar using five pre-specified search strings, and 40 articles formed the final evidence base. Each article was verified against its Crossref, PubMed or publisher record, screened for retractions and corrections, and appraised with design-specific quality criteria, and every claim in the text was checked against the cited abstract. Findings were coded under signal, noise and action and synthesised abductively into propositions. The synthesis indicates that AI improves outbreak detection substantially, chiefly by drawing on data whose errors are independent of routine reporting, but improves the attribution of outbreaks to causes and places only modestly and locally, and contributes little to the public health response unless response pathways are agreed in advance. Data sparsity is accordingly reframed as a problem of identification created by under-ascertainment and reporting delay rather than as a mere shortage of observations. The paper advances seven testable propositions and a confidence-to-response framework linking signal confidence, data quality and corroboration to tiered action. Agencies adopting AI alerts should attach pre-agreed response protocols to each alert and fund data quality alongside modelling, and model developers should validate models over time, at the level at which decisions are made, under independent governance.
References
Adefolalu, A. O. (2026). When is travel-health AI inference transportable? Mobility-conditioned admissibility for cross-border disease risk and decision support. Travel Medicine and Infectious Disease, 74, 103032. https://doi.org/10.1016/j.tmaid.2026.103032
Ahmad Amshi, H., Prasad, R., Sharma, B. K., Yusuf, S. I., & Sani, Z. (2024). How can machine learning predict cholera: Insights from experiments and design science for action research. Journal of Water and Health, 22(1), 21– 35. https://doi.org/10.2166/wh.2023.026
Alasow, A. A., Abdi, Y. H., Hersi, A. A., & Boakye, M. (2026). Artificial intelligence for climate–health early warning systems in the Horn of Africa: Opportunities, challenges, and a roadmap for action. Globalization and Health, 22(1), 63. https://doi.org/10.1186/s12992-026-01233-9
Al Wahaibi, A., Almayahi, Z. K., Al Shehi, R., Al Tobi, M., Nazer, W., Al Manji, A., Al Wahaibi, I., Al Hosni, S., Alhatali, B., Al Khalili, S., Farag, N., Al Busaidi, S., Al Mashaiki, A., Al Tobi, S., Al Jamodi, S., Zaghloul, A., & Al Maani, A. (2026). The evolution of EBS in Oman: From planning stages to practical application. Journal of Epidemiology and Global Health, 16(1), 57. https://doi.org/10.1007/s44197-026-00556-5
Ansah-Narh, T., Afrane, Y. A., & Tandoh, J. B. (2026). Hybrid probabilistic forecasting of under-five malaria admissions in Ghana: A Gaussian process regression with Holt–Winters smoothing. Artificial Intelligence in Medicine, 182, 103508. https://doi.org/10.1016/j.artmed.2026.103508
Awoyale, O. D., Jimoh, A., Dede, A., Rauf, R. I., Mustafa, A., Sowade, T. A., Gimba, P. B., Ibrahim, I., Akpen, C. N., Eugene, E. C., Erekosima, G. F., Okekeigwe, C., Tarfa, M. J., Isiaka, S. D., Okagbue, H., Atobatele, S., & Sampson, S. (2026). Evaluation of surveillance performance and determinants for priority vaccine-preventable diseases in Niger State, Nigeria: A CDC 2001 guideline-based multilevel analysis. PLOS Global Public Health, 6(9), e0005928. https://doi.org/10.1371/journal.pgph.0005928
Bakare, E. A., Daniel, D. O., Osikoya, S. A., & Nwana, A. O. (2026). Wavelet analysis and time series forecasting of malaria incidence across different transmission settings in Nigeria. BMC Infectious Diseases, 26(1), 1667. https://doi.org/10.1186/s12879-026-14226-1
Bakare, E. A., Mogbojuri, O. A., Oniyelu, D. O., Abidemi, A., Daniel, D. O., Olasupo, I. I., Osikoya, S. A., Nwana, A. O., Olorunfemi, R. D., & Olagbami, S. O. (2025). Time series modelling and forecasting of mpox incidence and mortality in Nigeria. BMC Infectious Diseases, 25(1), 794. https://doi.org/10.1186/s12879-025-11174-0
Bragazzi, N. L., Iyaniwura, S. A., Han, Q., Woldegerima, W. A., & Kong, J. D. (2024). Quantifying the basic reproduction number and underestimated fraction of Mpox cases worldwide at the onset of the outbreak. Journal of the Royal Society Interface, 21(216), 20230637. https://doi.org/10.1098/rsif.2023.0637
Collins, G. S., Moons, K. G. M., Dhiman, P., Riley, R. D., Beam, A. L., Van Calster, B., Ghassemi, M., Liu, X., Reitsma, J. B., van Smeden, M., Boulesteix, A.-L., Camaradou, J. C., Celi, L. A., Denaxas, S., Denniston, A. K., Glocker, B., Golub, R. M., Harvey, H., Heinze, G., . . .
Logullo, P. (2024). TRIPOD+AI statement: Updated guidance for reporting clinical prediction models that use regression or machine learning methods. BMJ, 385, e078378. https://doi.org/10.1136/bmj-2023-078378
Corrigendum. (2023). Journal of International Medical Research, 51(5), 03000605231178098. https://doi.org/10.1177/03000605231178098
Diop, B., Faye, S. L. B., Cisse, B., Sow, G. H. C., Ndao, A., Badiane, M., Diakhate, F., Dia, N., Ndiaye, F., Bocoum, M., Camara, B., Faye, F. N., Diop, R., Mbengue, M. R. H., Diongue, F. B., Thiam, O. A., Duclos, V., Ndiaye, D., Ba, M. L., . . . Ndiaye, M. (2026). Artificial intelligence-supported One Health surveillance for early warning of Rift Valley fever in Senegal. Frontiers in Tropical Diseases, 7, 1778438. https://doi.org/10.3389/fitd.2026.1778438
Edo, G. I., Enoch, O. O., Akpo, M. O., Fuwape, I. A., Itoje-Akpokiniovo, L. O., Makia, R. S., Yousif, E., Owheruo, J. O., Oghroro, E. E. A., Igbuku, U. A., Essaghah, A. E. A., Ahmed, D. S., Alamiery, A. A., & Umar, H. (2026). Analysis of Lassa fever incidence in Nigeria demonstrates a clear climate-disease interaction. EcoHealth. Advance online publication. https://doi.org/10.1007/s10393-026-01851-0
Egbom, S. E., Nduka, F. O., Nzeako, S. O., Nwafor, G. O., Bartholomew, D. C., Nwaigwe, C. C., Iwu, H. C., Ogbonna, C. J., Nwokike, C. I., Opara, M. C., Ezenwaka, C. O., Anyanwu, E. O., & Nwachukwu, J. I. (2026). Climatic and governance determinants of malaria transmission in Rivers State, Nigeria. Scientific Reports, 16(1), 5459. https://doi.org/10.1038/s41598-026-35029-z
Faye, S. L. B., Diongue, F. B., Ndao, A., Diop, B., Sow, G. H. C., Dia, N., Diakhate, F., Gadiaga, T., Dieye, P. S., Gueye, O. K. D., Sall, Y., Seck, I., Gueye, Y. B., Massaly, A., Seydi, M., & Sy, I. (2026). Advancing epidemic intelligence: Evaluating Senegal's mpox surveillance system and readiness for AI-driven predictive modelling. Frontiers in Public Health, 14, 1742888. https://doi.org/10.3389/fpubh.2026.1742888
Fofanah, A. J., Kamara, A. A., Sankoh, A. P., Gao, T., Dumbuya, I., & Conteh, Z. B. (2025). DeepEVD: Integrating epidemiological data into deep learning frameworks based on spatio-temporal feature learning for EVD forecasting. Spatial and Spatio-temporal Epidemiology, 54, 100741. https://doi.org/10.1016/j.sste.2025.100741
Gbaguidi, G. J., Topanou, N., Filho, W. L., & Ketoh, G. K. (2024). Towards an intelligent malaria outbreak warning model based intelligent malaria outbreak warning in the northern part of Benin, West Africa. BMC Public Health, 24(1), 450. https://doi.org/10.1186/s12889-024-17847-w
John, O. N., Akyala, A. I., Eleojo, G. I., Aremu, S. O., Matthew, A. O., Elam, O. P., Ezeobi, A. J., Augustine, O., Barnabas, S., Augustine, U., Ayo, O. J., Mohammed, K., Ameh, A. J., Ohize, M. S., Thankgod, O. S., & Barkhadle, A. A. (2026). Impact of seasonal changes on the epidemiology of Lassa fever in a state in North Central, Nigeria. Tropical Diseases, Travel Medicine and Vaccines, 12(1), 12. https://doi.org/10.1186/s40794-026-00294-3
Kalahasti, S., Faucher, B., Wang, B., Ascione, C., Carbajal, R., Enault, M., Cassis, C. V., Launay, T., Guerrisi, C., Boëlle, P. Y., Baldo, F., & Valdano, E. (2026). Foundation models for time series forecasting and policy evaluation in infectious disease epidemics. Epidemics, 55, 100916. https://doi.org/10.1016/j.epidem.2026.100916
Keshavamurthy, R., & Charles, L. E. (2023). Predicting Kyasanur forest disease in resource-limited settings using event-based surveillance and transfer learning. Scientific Reports, 13(1), 11067. https://doi.org/10.1038/s41598-023-38074-0
Keshavamurthy, R., Pazdernik, K. T., Ham, C., Dixon, S., Erwin, S., & Charles, L. E. (2025). Meeting global health needs via infectious disease forecasting: Development of a reliable data-driven framework. JMIR Public Health and Surveillance, 11, e59971. https://doi.org/10.2196/59971
Khan, O., Ajadi, J. O., & Hossain, M. P. (2024). Predicting malaria outbreak in The Gambia using machine learning techniques. PLOS ONE, 19(5), e0299386. https://doi.org/10.1371/journal.pone.0299386
Khurana, M. P., Tsui, J. L.-H., Gutierrez, B., Chopra, A., Scheidwasser, N., Zhu, H. B. H., Chang, S. Y., Duchêne, D. A., Mills, C., Inward, R. P. D., Reddy, B., Brittain, J., Dasgupta, A., Sheldon, J., Githinji, G., Brownstein, J. S., Monod, M., Ferretti, L., Bershan, S., . . . Kraemer, M. U. G. (2026). Global approaches to infectious disease surveillance and modeling. Nature Medicine, 32(5), 1646– 1660. https://doi.org/10.1038/s41591-026-04351-4
Kogan, N. E., Gantt, S., Swerdlow, D., Viboud, C., Semakula, M., Lipsitch, M., & Santillana, M. (2023). Leveraging serosurveillance and postmortem surveillance to quantify the impact of coronavirus disease 2019 in Africa. Clinical Infectious Diseases, 76(3), 424–432. https://doi.org/10.1093/cid/ciac797
Kraemer, M. U. G., Tsui, J. L.-H., Chang, S. Y., Lytras, S., Khurana, M. P., Vanderslott, S., Bajaj, S., Scheidwasser, N., Curran-Sebastian, J. L., Semenova, E., Zhang, M., Unwin, H. J. T., Watson, O. J., Mills, C., Dasgupta, A., Ferretti, L., Scarpino, S. V., Koua, E., Morgan, O., . . .
Bhatt, S. (2025). Artificial intelligence for modelling infectious disease epidemics. Nature, 638(8051), 623– 635. https://doi.org/10.1038/s41586-024-08564-w
Layman, N. C., Basinski, A. J., Zhang, B., Eskew, E. A., Bird, B. H., Ghersi, B. M., Bangura, J., Fichet-Calvet, E., Remien, C. H., Vandi, M., Bah, M., & Nuismer, S. L. (2023). Predicting the fine-scale spatial distribution of zoonotic reservoirs using computer vision. Ecology Letters, 26(11), 1974–1986. https://doi.org/10.1111/ele.14307
MacIntyre, C. R., Chen, X., Kunasekaran, M., Quigley, A., Lim, S., Stone, H., Paik, H.-Y., Yao, L., Heslop, D., Wei, W., Sarmiento, I., & Gurdasani, D. (2023). Artificial intelligence in public health: The potential of epidemic early warning systems. Journal of International Medical Research, 51(3), 03000605231159335. https://doi.org/10.1177/03000605231159335
McArthur, A., Klugárová, J., Yan, H., & Florescu, S. (2015). Innovations in the systematic review of text and opinion. International Journal of Evidence-Based Healthcare, 13(3), 188–195. https://doi.org/10.1097/XEB.0000000000000060
Mohamed, A. O., Afyare, A., Abdi, A. M., Muhumed, Y. H., & Abdihashi, M. A. (2026). Artificial intelligence is transforming disease surveillance, but governance is failing to keep pace. Frontiers in Digital Health, 8, 1939009. https://doi.org/10.3389/fdgth.2026.1939009
Moons, K. G. M., Damen, J. A. A., Kaul, T., Hooft, L., Andaur Navarro, C., Dhiman, P., Beam, A. L., Van Calster, B., Celi, L. A., Denaxas, S., Denniston, A. K., Ghassemi, M., Heinze, G., Kengne, A. P., Maier-Hein, L., Liu, X., Logullo, P., McCradden, M. D., Liu, N., . . . van Smeden, M. (2025). PROBAST+AI: An updated quality, risk of bias, and applicability assessment tool for prediction models using regression or artificial intelligence methods. BMJ, 388, e082505. https://doi.org/10.1136/bmj-2024-082505
Mukherjee, D., Sagar, K., Kobialka, R. M., Ghosh, P., Weidmann, M., Savareh, B. A., Joardar, S. N., Truyen, U., Abd El Wahed, A., & Ceruti, A. (2025). Filling the gap: Artificial intelligence-driven one health integration to strengthen pandemic preparedness in resource-limited settings. Frontiers in Public Health, 13, 1707306. https://doi.org/10.3389/fpubh.2025.1707306
Ngufor, C., Lindblade, K. A., Atobatele, S., Mpimbaza, A., Ahogni, I., Ssewante, N., Akpiroroh, E., Kpemasse, A., Okoro, O., Agaba, B., Cooper, S., Griffith, K., & Humes, M. (2025). Are malaria rapid diagnostic test results stable over time to support verification of surveillance data? Malaria Journal, 24(1), 356. https://doi.org/10.1186/s12936-025-05595-0
Nia, Z. M., Seyyed-Kalantari, L., Goitom, M., Mellado, B., Ahmadi, A., Asgary, A., Orbinski, J., Wu, J., & Kong, J. D. (2025). Leveraging deep-learning and unconventional data for real-time surveillance, forecasting, and early warning of respiratory pathogens outbreak. Artificial Intelligence in Medicine, 161, 103076. https://doi.org/10.1016/j.artmed.2025.103076
Nsawotebba, A., Nabadda, S., Hull, N., Nakintu, V., Morunyanga, I., Magala, J., Kabazzi, J., Mutyaba, S. J., Akejo, D. S., Makoha, C., Dambya, C., Bwogi, J., Najjuka, G., Bolding, A., Ikoba, S., Snyder, S., Etimu, S., Uragiwenimana, V., Cham, F., . . . Olaro, C. (2026). Real-time public health interventions driven by wastewater and environmental surveillance during Uganda's 2025 martyrs day mass gathering. Journal of Health, Population and Nutrition, 45(1), 88. https://doi.org/10.1186/s41043-026-01253-6
Opue, J. A., Okorie, U. E., & Itita, V. E. (2026). Topological data analysis for predicting disease outbreaks in humanitarian settings: A machine learning approach. PLOS ONE, 21(6), e0350644. https://doi.org/10.1371/journal.pone.0350644
Pezanowski, S., Koua, E. L., Okeibunor, J. C., & Gueye, A. S. (2024). Predictors of disease outbreaks at continental-scale in the African region: Insights and predictions with geospatial artificial intelligence using earth observations and routine disease surveillance data. Digital Health, 10, 20552076241278939. https://doi.org/10.1177/20552076241278939
Pham, C. T., Nguyen, H. T., Le, H. H. T. C., Tran, N. Q. L., Do, K. Q., Bui, V., Phung, H., Phung, D., & Chu, C. (2026). Challenges and strategies for the development and implementation of climate-informed early warning systems for vector-borne diseases: A systematic review. Tropical Medicine & International Health, 31(1), 10–21. https://doi.org/10.1111/tmi.70045
Quigley, A., Honeyman, D., Stone, H., Dawson, R., & MacIntyre, C. R. (2025). EPIWATCH, an artificial intelligence early-warning system as a valuable tool in outbreak surveillance. International Journal of Infectious Diseases, 152, 107579. https://doi.org/10.1016/j.ijid.2024.107579
Samson, T. K., Aromolaran, O., & Akingbade, T. (2024). The Lassa fever cases and mortality in Nigeria: Quantile regression versus machine learning models. Journal of Public Health in Africa, 14(12), 2712. https://doi.org/10.4081/jphia.2023.2712
Shea, B. J., Reeves, B. C., Wells, G., Thuku, M., Hamel, C., Moran, J., Moher, D., Tugwell, P., Welch, V., Kristjansson, E., & Henry, D. A. (2017). AMSTAR 2: A critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ, 358, j4008. https://doi.org/10.1136/bmj.j4008
Song, P., Jiang, D., Zhou, J., Zhu, Y., Manaf, R. A., Bojude, D. A., Agbre-Yace, M. L., Ali, S., Allen, O., Anyasodor, A. E., Aranda, Z., Bahattab, A., Bodomo, A., Borrescio-Higa, F., Buchtova, M., Buljan, N., Deshmukh, V., Díaz-Castro, L., Cheema, S., . . . Rudan, I. (2026). Research priorities for data science and artificial intelligence in global health: An international consensus exercise. The Lancet Global Health, 14(3), e455–e465. https://doi.org/10.1016/S2214-109X(25)00473-5
Standley, C. J., Breugelmans, J. G., Chaudhari, A., Cherian, N., Chwalek, S., Deol, A., Dietrich, J., du Moulin, L., Otim, G., James, W., Kloth, S., Masmoudi, S., Ndembi, N., Ndlovu, N., Scarponi, D., Schnetzinger, F., Shapiro, M., & Hebbeler, A. (2025). Artificial intelligence for health security in Africa: Benefits, risks and opportunities. Epidemics, 53, 100870. https://doi.org/10.1016/j.epidem.2025.100870
Tadema, A. J., Nwosu, F. M., & Abimbola, O. A. (2026). Temporal dynamics, climate associations, and surveillance performance of Lassa fever in Nigeria, 2020–2025: A national longitudinal analysis. Osong Public Health and Research Perspectives, 17(4), 310–321. https://doi.org/10.24171/j.phrp.2026.0226
Tahlil, A. A., Ahmed, H. S., Nur, I. M., Mohamed, S. I., Mohamed, M. A., Ahmed, A. Y., Hussein, S. A., Sultan, K. M., Mohamud, A. K., Ismail, A. A., Dahir, A., Osman, A. Y., Kamil, M. A., Mohamed, M. H., & Adam, A. H. (2026). Leveraging artificial intelligence to strengthen public health emergency preparedness and response for infectious disease outbreaks in Somalia. Discover Artificial Intelligence, 6(1), 1302. https://doi.org/10.1007/s44163-026-01690-6
Villanueva-Miranda, I., Xiao, G., & Xie, Y. (2025). Artificial intelligence in early warning systems for infectious disease surveillance: A systematic review. Frontiers in Public Health, 13, 1609615. https://doi.org/10.3389/fpubh.2025.1609615
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